منابع مشابه
Cell-cell fusion induced by the avian reovirus membrane fusion protein is regulated by protein degradation.
The p10 fusion-associated small transmembrane protein of avian reovirus induces extensive syncytium formation in transfected cells. Here we show that p10-induced cell-cell fusion is restricted by rapid degradation of the majority of newly synthesized p10. The small ectodomain of p10 targets the protein for degradation following p10 insertion into an early membrane compartment. Paradoxically, co...
متن کاملCell fusion induced senescence
senescence has long been established as a stable and irreversible growth arrest, which plays an important role in tumor suppression and tissue repair. It can be induced by various stimuli, including telomere shortening, oncogene activation and oxidative stress. We recently demonstrated that cell-cell fusion is a previously unidentified trigger for inducing cellular senescence [1]. This work was...
متن کاملEstimating intercellular surface tension by laser-induced cell fusion.
Intercellular surface tension is a key variable in understanding cellular mechanics. However, conventional methods are not well suited for measuring the absolute magnitude of intercellular surface tension because these methods require determination of the effective viscosity of the whole cell, a quantity that is difficult to measure. In this study, we present a novel method for estimating the i...
متن کاملCell fusion induced by the murine leukemia virus envelope glycoprotein.
To determine whether ecotropic murine leukemia virus (MuLV) envelope glycoproteins are sufficient to cause cell-to-cell fusion when expressed in the absence of virus production, we used an ecotropic MuLV, AKV, to construct env expression vectors that lack the gag and pol genes. The rat cell line XC, which undergoes cell-to-cell fusion upon infection with ecotropic MuLV, was transfected with wil...
متن کاملFactors affecting cell fusion induced by Sendai virus.
Cell fusion mediated by exogenous Sendai virus appears to occur in four temperature-dependent stages. The first two, which include viral adsorption, are pH dependent and can be inhibited by viral antibody. Viral envelope constituents remain detectable on the cell surface during the third stage and disappear only when cell-to-cell fusion supervenes. The relationship of these interactions to poss...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 1974
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197405000-00010